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metaMIR 3236723

Input and runtime details for job 3236723 (precomputed example)

Input

? List of genes analyzed
*YAP1 *WWTR1 *TP73 *TEAD1 *TEAD2 *AJUBA BMP2 BMP4 BMP7 BMPR1A BMPR2 MYC NOG SMAD1 SMAD2 SMAD3 SMAD4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 -NF1 -NF2 -PTEN -TP53 -CHD5 -FOXD3
? Minimum number of genes per cluster5
? Maximum number of genes per cluster15
? Minimum score to return1.1

Job ID 3236723 (server version 4.3.0)

?Job Submitted & Queued@ Wed Aug 10 06:55:28 CEST 2016
?metaMIR Started@ Wed Aug 10 06:55:39 CEST 2016
?metaMIR Finished & Post-Processing@ Wed Aug 10 06:57:23 CEST 2016
?Job Completed@ Wed Aug 10 06:57:23 CEST 2016
 DIRECT ACCESS: http://rna.informatik.uni-freiburg.de/RetrieveResults.jsp?jobID=3236723&toolName=metaMIR ( 30 days expiry )

Description of the job

Combined differential and core analysis

As described, the Hippo/YAP pathway is involved in regulation of cell proliferation (specifically at the transcriptional co-activation, or nuclear component end) and the TGFb signalling pathway can be dysregulated (by overactivity) in many cancers (see example descriptions for core and differential analyses above). It is thus feasible that miRNAs may exist that simultaneously target members of both of these pathways, as both may encourage normal or pathological cell proliferation.

This gene list is a combination of the core and differential analyses. The core is set to the YAP-related members of the Hippo/YAP signalling pathway (marked with asterisks), the TGFb genes are as previously (to be targeted in any combination; any, all or none may be returned in the final list), and in a hypothetical therapeutic context, any returned miRNA is not to target tumour suppressors (prefixed with minus signs).

? Output download complete results [zip]

Result table

Sort by selecting a column name.
miRNA Final Score Positive Combo Positive Score Positive Group Positive List
hsa-miR-6508-5p 2.218 SMAD2,SMAD3,TEAD1,TGFBR3,TP73,YAP1 2.067 6 1.9
hsa-miR-5681a 1.813 BMPR2,SMAD1,SMAD3,TEAD1,TGFBR3,WWTR1,YAP1 1.462 7 1.81
hsa-miR-548az-5p 1.222 AJUBA,BMPR2,SMAD1,SMAD4,TEAD1,TGFBR3 1.197 6 1.21
hsa-miR-4695-5p 2.307 BMP2,BMPR2,SMAD1,SMAD3,SMAD4,TEAD1,WWTR1 1.17 7 2.31

Result table - repPos

Show rows: 1-10 11-20 21-23 all
Sort by selecting a column name.
Gene name Rep
AJUBA 80
BMP2 80
BMP4 10
BMP7 40
BMPR1A 100
BMPR2 100
MYC 10
NOG 10
SMAD1 10
SMAD2 100
Rows: 1-10 11-20 21-23 all

Result table - clusterPos

Show rows: 1-10 11-20 21-30 31-37 all
Sort by selecting a column name.
Gene 1 Inter Gene 2 Norm
AJUBA pp BMP2 19
BMPR1A pp BMPR2 23
SMAD2 pp SMAD3 23
SMAD4 pp TEAD1 23
TGFB2 pp TGFBR1 20
TGFBR2 pp TGFBR3 23
TP73 pp WWTR1 18
YAP1 pp AJUBA 19
BMP2 pp BMPR1A 15
BMPR2 pp SMAD2 20
Rows: 1-10 11-20 21-30 31-37 all

Job resubmission

Use the following button if you want to resubmit the job with altered input or parameterization:
Feeds the job parameters to the input page to resubmit the job.

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Results are computed with metaMIR version 1.0.0 using R 3.2.1
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