Annotation Cluster 1 Enrichment Score: 1.2599680459736322 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006631~fattyacidmetabolicprocess 4 8.0 0.031180863837898577 945568,947262,947528,947525 35 47 2287 5.5610942249240125 0.9956972526169884 0.9344046695029925 32.10590978173453 GOTERM_BP_FAT GO:0019395~fattyacidoxidation 3 6.0 0.06373796074270446 947262,947528,947525 35 28 2287 7.001020408163265 0.9999879675122848 0.9411035854789694 55.29415557835201 GOTERM_BP_FAT GO:0034440~lipidoxidation 3 6.0 0.06373796074270446 947262,947528,947525 35 28 2287 7.001020408163265 0.9999879675122848 0.9411035854789694 55.29415557835201 GOTERM_BP_FAT GO:0030258~lipidmodification 3 6.0 0.07201837943436383 947262,947528,947525 35 30 2287 6.534285714285715 0.9999973892068986 0.9235540483712606 59.89450093275093 Annotation Cluster 2 Enrichment Score: 1.255282455892308 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY ect00640:Propanoatemetabolism 3 6.0 0.049928532437282236 947528,947525,945446 18 24 1111 7.715277777777778 0.9999999873095261 0.9999999873095261 50.43948801517926 KEGG_PATHWAY eum00640:Propanoatemetabolism 3 6.0 0.049928532437282236 947528,947525,945446 18 24 1111 7.715277777777778 0.9999999873095261 0.9999999873095261 50.43948801517926 KEGG_PATHWAY ecj00640:Propanoatemetabolism 3 6.0 0.06181392022250009 947528,947525,945446 18 27 1111 6.8580246913580245 0.9999999998545915 0.9999879414576242 58.29355908526841 KEGG_PATHWAY eco00640:Propanoatemetabolism 3 6.0 0.06181392022250009 947528,947525,945446 18 27 1111 6.8580246913580245 0.9999999998545915 0.9999879414576242 58.29355908526841 Annotation Cluster 3 Enrichment Score: 1.123982191723097 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY ecd00650:Butanoatemetabolism 3 6.0 0.06181392022250009 945316,947525,945446 18 27 1111 6.8580246913580245 0.9999999998545915 0.9999879414576242 58.29355908526841 KEGG_PATHWAY ect00650:Butanoatemetabolism 3 6.0 0.0745810611858935 945316,947525,945446 18 30 1111 6.1722222222222225 0.9999999999988777 0.9998960777185955 65.43421728374987 KEGG_PATHWAY eum00650:Butanoatemetabolism 3 6.0 0.0745810611858935 945316,947525,945446 18 30 1111 6.1722222222222225 0.9999999999988777 0.9998960777185955 65.43421728374987 KEGG_PATHWAY ecj00650:Butanoatemetabolism 3 6.0 0.08353583509767129 945316,947525,945446 18 32 1111 5.786458333333333 0.9999999999999645 0.999565740261191 69.74696387528563 KEGG_PATHWAY eco00650:Butanoatemetabolism 3 6.0 0.08353583509767129 945316,947525,945446 18 32 1111 5.786458333333333 0.9999999999999645 0.999565740261191 69.74696387528563 Annotation Cluster 4 Enrichment Score: 0.9330665277551283 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031975~envelope 14 28.000000000000004 0.0038973186653216405 946138,945168,947579,946843,945580,945316,948351,1450292,947537,947740,945026,947487,946537,947030 18 572 1366 1.8574203574203574 0.07512682597877174 0.07512682597877174 2.928282720888642 GOTERM_CC_FAT GO:0019866~organelleinnermembrane 11 22.0 0.02359033651047833 945168,946138,947579,945580,947487,945316,948351,947537,947030,945026,947740 18 448 1366 1.8633432539682542 0.37964343973309267 0.21237282914636102 16.614503184279805 GOTERM_CC_FAT GO:0031967~organelleenvelope 11 22.0 0.02359033651047833 945168,946138,947579,945580,947487,945316,948351,947537,947030,945026,947740 18 448 1366 1.8633432539682542 0.37964343973309267 0.21237282914636102 16.614503184279805 GOTERM_CC_FAT GO:0031090~organellemembrane 11 22.0 0.023972829631614005 945168,946138,947579,945580,947487,945316,948351,947537,947030,945026,947740 18 449 1366 1.8591932689928237 0.3844856931079996 0.14935951070284736 16.86279182763132 GOTERM_CC_FAT GO:0030312~externalencapsulatingstructure 13 26.0 0.04471392858908482 946138,945168,947579,946843,945316,948351,1450292,947537,947740,945026,947487,946537,947030 18 646 1366 1.5271757825937393 0.5994387710341641 0.20445046228061448 29.401207863511637 GOTERM_CC_FAT GO:0005886~plasmamembrane 15 30.0 0.07413137547839377 946138,947579,946843,945580,945316,948351,1450292,947537,948174,947740,945026,946717,947487,948193,946537 18 860 1366 1.3236434108527133 0.7857171850679155 0.26515208112288247 44.35707448234306 GOTERM_CC_FAT GO:0031224~intrinsictomembrane 14 28.000000000000004 0.09835632204434577 946138,947579,946843,945316,948351,1450292,947537,948174,947740,945026,946717,947487,948193,946537 18 797 1366 1.3330545099679352 0.873904717796768 0.29186432690029507 54.524801629582406 GOTERM_CC_FAT GO:0016021~integraltomembrane 13 26.0 0.12273960923579079 946138,947579,946843,945316,948351,947537,948174,947740,945026,946717,947487,948193,946537 18 734 1366 1.3440811383590676 0.9271263673729979 0.3121241541626192 63.08900085148679 SP_PIR_KEYWORDS transport 13 26.0 0.126478974200253 946138,946409,947579,946843,948193,945316,947487,946537,948351,944980,948174,945026,947740 50 586 3389 1.503651877133106 0.9999965452012183 0.98488269927116 77.24425414004577 GOTERM_CC_FAT GO:0009274~peptidoglycan-basedcellwall 11 22.0 0.14408872082915133 945168,946138,947579,947487,945316,946537,948351,947537,947030,945026,947740 18 590 1366 1.4148775894538608 0.9554779666465475 0.3222463364109449 69.40005034916213 GOTERM_CC_FAT GO:0005618~cellwall 11 22.0 0.14694876367820675 945168,946138,947579,947487,945316,946537,948351,947537,947030,945026,947740 18 592 1366 1.4100975975975976 0.9583608040645404 0.29755654470933857 70.1697267956179 SP_PIR_KEYWORDS cellmembrane 15 30.0 0.3519940948026427 946138,947579,946843,945580,945316,948351,1450292,947537,948174,947740,945026,946717,947487,948193,946537 50 859 3389 1.1835855646100117 1.0 0.9744738226183384 99.13450672276993 SP_PIR_KEYWORDS transmembrane 13 26.0 0.35585548830605274 946138,947579,946843,945316,948351,947537,948174,947740,945026,946717,947487,948193,946537 50 728 3389 1.210357142857143 1.0 0.9669157983749285 99.18932303720048 UP_SEQ_FEATURE topologicaldomain:Cytoplasmic 9 18.0 0.37323549555256985 946138,946717,947579,947487,945316,948351,947537,948174,947740 50 463 3322 1.2914902807775377 1.0 0.9999999998176059 99.41747526812867 UP_SEQ_FEATURE topologicaldomain:Periplasmic 9 18.0 0.375611178676029 946138,946717,947579,947487,945316,948351,947537,948174,947740 50 464 3322 1.288706896551724 1.0 0.9999997151843746 99.44133775975159 SP_PIR_KEYWORDS membrane 15 30.0 0.4386862287525443 946138,947579,946843,945580,945316,948351,1450292,947537,948174,947740,945026,946717,947487,948193,946537 50 906 3389 1.122185430463576 1.0 0.9839359094940587 99.82034746154352 UP_SEQ_FEATURE transmembraneregion 11 22.0 0.602458810989394 946138,946717,947579,948193,947487,945316,948351,947537,948174,945026,947740 50 700 3322 1.044057142857143 1.0 0.9999999997572433 99.99613091916144 SP_PIR_KEYWORDS cellinnermembrane 10 20.0 0.6197135543807238 946138,946717,947579,947487,945316,948351,947537,948174,945026,947740 50 652 3389 1.0395705521472394 1.0 0.9975072010836571 99.9974691280943 Annotation Cluster 5 Enrichment Score: 0.8384795172195156 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS iron 8 16.0 0.015760481905424582 947461,945963,948076,945580,945316,947262,945465,944980 50 185 3389 2.931027027027027 0.7717692027202483 0.7717692027202483 15.962891757491803 GOTERM_MF_FAT GO:0005506~ironionbinding 7 14.000000000000002 0.07557095923120855 947461,945963,948076,945316,947262,945465,944980 35 191 2145 2.2460732984293195 0.9999060098212069 0.9999060098212069 59.31407593745439 GOTERM_MF_FAT GO:0046872~metalionbinding 13 26.0 0.11846994729741017 947461,945963,948076,946434,945580,945316,945465,947262,948403,947072,948351,944980,947420 35 537 2145 1.4836392657621709 0.9999996548717792 0.9994125238551788 76.38039339373648 SP_PIR_KEYWORDS metal-binding 10 20.0 0.12432936389758599 945963,948076,946434,945580,945316,947262,945465,948403,944980,947420 50 406 3389 1.6694581280788177 0.999995657966532 0.9979162453436049 76.62365116654077 GOTERM_MF_FAT GO:0043167~ionbinding 13 26.0 0.1334180736979297 947461,945963,948076,946434,945580,945316,945465,947262,948403,947072,948351,944980,947420 35 548 2145 1.4538581856100106 0.9999999541292345 0.9964203107359505 80.57909089808544 GOTERM_MF_FAT GO:0043169~cationbinding 13 26.0 0.1334180736979297 947461,945963,948076,946434,945580,945316,945465,947262,948403,947072,948351,944980,947420 35 548 2145 1.4538581856100106 0.9999999541292345 0.9964203107359505 80.57909089808544 SP_PIR_KEYWORDS iron-sulfur 4 8.0 0.18911346837133022 945963,947262,945465,944980 50 104 3389 2.606923076923077 0.9999999965858067 0.9611955662965876 89.92275074692353 GOTERM_MF_FAT GO:0046914~transitionmetalionbinding 10 20.0 0.1903665465842018 947461,945963,948076,945580,945316,947262,945465,948403,948351,944980 35 412 2145 1.4875173370319001 0.9999999999849327 0.9980298054432262 91.07891168973562 GOTERM_MF_FAT GO:0051536~iron-sulfurclusterbinding 4 8.0 0.2604565005910452 945963,947262,945465,944980 35 112 2145 2.188775510204082 0.9999999999999997 0.9991917534013153 96.83502213956514 GOTERM_MF_FAT GO:0051540~metalclusterbinding 4 8.0 0.2604565005910452 945963,947262,945465,944980 35 112 2145 2.188775510204082 0.9999999999999997 0.9991917534013153 96.83502213956514 SP_PIR_KEYWORDS 4fe-4s 3 6.0 0.3173137460510156 947262,945465,944980 50 79 3389 2.573924050632911 0.9999999999999997 0.9712752159531762 98.46842324636728 GOTERM_MF_FAT GO:0051539~4iron,4sulfurclusterbinding 3 6.0 0.3584575623673697 947262,945465,944980 35 79 2145 2.3273056057866186 1.0 0.9998382791546737 99.37796683695525 Annotation Cluster 6 Enrichment Score: 0.6362683306834923 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0005996~monosaccharidemetabolicprocess 6 12.0 0.03191111126225757 947599,947487,947262,947420,947740,945358 35 122 2287 3.2135831381733024 0.9962206204333809 0.8442337001533207 32.72883160711375 GOTERM_BP_FAT GO:0034637~cellularcarbohydratebiosyntheticprocess 3 6.0 0.5495700040373865 947262,947740,945358 35 122 2287 1.6067915690866512 1.0 0.9995099770023333 99.99416597888103 GOTERM_BP_FAT GO:0016051~carbohydratebiosyntheticprocess 3 6.0 0.7034448576648553 947262,947740,945358 35 161 2287 1.2175687666370896 1.0 0.9999525438685284 99.99996475808106 Annotation Cluster 7 Enrichment Score: 0.40202864837755586 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS oxidoreductase 8 16.0 0.19271760745532102 945779,947003,945963,945580,945316,945933,948403,944980 50 329 3389 1.648145896656535 0.9999999977438412 0.9418208870610207 90.40239386589907 GOTERM_BP_FAT GO:0055114~oxidationreduction 7 14.000000000000002 0.43382329315339396 947003,945963,945580,945316,945933,948403,944980 35 354 2287 1.2920903954802259 1.0 0.9977908053704667 99.90447763347382 GOTERM_BP_FAT GO:0006091~generationofprecursormetabolitesandenergy 5 10.0 0.46840830351177315 947003,945580,945316,947528,944980 35 235 2287 1.390273556231003 1.0 0.998326996047288 99.95579312389923 GOTERM_MF_FAT GO:0009055~electroncarrieractivity 3 6.0 0.6295446812733416 945963,945316,944980 35 132 2145 1.3928571428571428 1.0 0.9999999462821834 99.99884002738708 Annotation Cluster 8 Enrichment Score: 0.3845747375696324 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0009060~aerobicrespiration 3 6.0 0.22365798995993336 945580,945316,947528 35 60 2287 3.2671428571428573 1.0 0.9920787751268 95.47083880411475 GOTERM_BP_FAT GO:0015980~energyderivationbyoxidationoforganiccompounds 4 8.0 0.432978179048659 947003,945580,945316,947528 35 161 2287 1.6234250221827862 1.0 0.9985051048837542 99.90272003296022 GOTERM_BP_FAT GO:0006091~generationofprecursormetabolitesandenergy 5 10.0 0.46840830351177315 947003,945580,945316,947528,944980 35 235 2287 1.390273556231003 1.0 0.998326996047288 99.95579312389923 GOTERM_BP_FAT GO:0045333~cellularrespiration 3 6.0 0.6383017532683541 945580,945316,947528 35 143 2287 1.3708291708291709 1.0 0.9998995678624099 99.99960073437312 Annotation Cluster 9 Enrichment Score: 0.2476848021658603 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0009279~celloutermembrane 3 6.0 0.32878587661415404 946843,946537,1450292 18 94 1366 2.4219858156028367 0.999655474221353 0.5494716005673703 95.18879549573953 GOTERM_CC_FAT GO:0019867~outermembrane 3 6.0 0.3476564499579479 946843,946537,1450292 18 98 1366 2.32312925170068 0.999805227582691 0.5400778625112402 96.12747017420199 GOTERM_CC_FAT GO:0044462~externalencapsulatingstructurepart 3 6.0 0.4918408783843815 946843,946537,1450292 18 130 1366 1.751282051282051 0.9999986817599131 0.6764066836974694 99.42138746331625 GOTERM_CC_FAT GO:0030313~cellenvelope 3 6.0 0.6483295710013418 946843,946537,1450292 18 171 1366 1.331384015594542 0.9999999991630163 0.799669320818617 99.9648701010314 SP_PIR_KEYWORDS signal 4 8.0 0.9438752029675981 946409,946843,946537,1450292 50 405 3389 0.6694320987654321 1.0 0.9999857775378762 99.99999999999798 UP_SEQ_FEATURE signalpeptide 4 8.0 0.9490579105888768 946409,946843,946537,1450292 50 405 3322 0.6561975308641975 1.0 1.0 99.99999999999942 Annotation Cluster 10 Enrichment Score: 0.1478223499543434 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0016310~phosphorylation 3 6.0 0.21261282097267034 946717,948525,945358 35 58 2287 3.3798029556650246 1.0 0.9941379531253517 94.61712126812192 GOTERM_BP_FAT GO:0006796~phosphatemetabolicprocess 3 6.0 0.26264467243139 946717,948525,945358 35 67 2287 2.925799573560768 1.0 0.9873127414929093 97.58736230082535 GOTERM_BP_FAT GO:0006793~phosphorusmetabolicprocess 3 6.0 0.36808814193348716 946717,948525,945358 35 86 2287 2.279401993355482 1.0 0.9976957360686304 99.63420216104562 SP_PIR_KEYWORDS kinase 3 6.0 0.583940339986432 946717,948525,945358 50 134 3389 1.5174626865671643 1.0 0.9970480763358277 99.99322807572749 SP_PIR_KEYWORDS atp-binding 4 8.0 0.8671551830352557 945963,946717,948525,945358 50 328 3389 0.8265853658536585 1.0 0.9999488315115205 99.99999997471697 SP_PIR_KEYWORDS nucleotide-binding 4 8.0 0.9081896817222027 945963,946717,948525,945358 50 362 3389 0.748950276243094 1.0 0.9999744676436367 99.99999999955713 GOTERM_MF_FAT GO:0005524~ATPbinding 4 8.0 0.9253275804904822 945963,946717,948525,945358 35 341 2145 0.7188940092165899 1.0 0.9999999999999495 99.9999999999873 GOTERM_MF_FAT GO:0032559~adenylribonucleotidebinding 4 8.0 0.9262985894351765 945963,946717,948525,945358 35 342 2145 0.7167919799498748 1.0 0.9999999999992902 99.99999999998906 GOTERM_MF_FAT GO:0032555~purineribonucleotidebinding 4 8.0 0.9520496994793132 945963,946717,948525,945358 35 374 2145 0.6554621848739496 1.0 0.9999999999998934 99.99999999999993 GOTERM_MF_FAT GO:0032553~ribonucleotidebinding 4 8.0 0.9520496994793132 945963,946717,948525,945358 35 374 2145 0.6554621848739496 1.0 0.9999999999998934 99.99999999999993 GOTERM_MF_FAT GO:0001883~purinenucleosidebinding 4 8.0 0.9570757141633168 945963,946717,948525,945358 35 382 2145 0.6417352281226627 1.0 0.9999999999996118 99.99999999999997 GOTERM_MF_FAT GO:0030554~adenylnucleotidebinding 4 8.0 0.9570757141633168 945963,946717,948525,945358 35 382 2145 0.6417352281226627 1.0 0.9999999999996118 99.99999999999997 GOTERM_MF_FAT GO:0001882~nucleosidebinding 4 8.0 0.9605294294147514 945963,946717,948525,945358 35 388 2145 0.6318114874815906 1.0 0.9999999999985257 99.99999999999999 GOTERM_MF_FAT GO:0000166~nucleotidebinding 5 10.0 0.9645593148144649 945963,946717,947263,948525,945358 35 480 2145 0.6383928571428571 1.0 0.9999999999961148 100.0 GOTERM_MF_FAT GO:0017076~purinenucleotidebinding 4 8.0 0.972780944280829 945963,946717,948525,945358 35 414 2145 0.5921325051759834 1.0 0.9999999999971346 100.0 Annotation Cluster 11 Enrichment Score: 0.04595949185731461 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR UP_SEQ_FEATURE DNA-bindingregion:H-T-Hmotif 3 6.0 0.7621434063861826 948427,947466,947030 50 183 3322 1.0891803278688523 1.0 0.9999999999989402 99.99998648687503 GOTERM_MF_FAT GO:0003700~transcriptionfactoractivity 3 6.0 0.7907120988720777 948427,947466,947030 35 179 2145 1.0271348762968875 1.0 0.9999999999042859 99.99999831602508 GOTERM_BP_FAT GO:0045449~regulationoftranscription 4 8.0 0.8747473845179657 947263,948427,947466,947030 35 320 2287 0.8167857142857143 1.0 0.9999999116242342 99.99999999906369 GOTERM_MF_FAT GO:0030528~transcriptionregulatoractivity 3 6.0 0.8883483511666057 948427,947466,947030 35 226 2145 0.8135271807838179 1.0 0.9999999999996716 99.99999999873117 SP_PIR_KEYWORDS Transcription 3 6.0 0.9203528344744436 948427,947466,947030 50 278 3389 0.7314388489208633 1.0 0.9999773563057532 99.99999999990655 SP_PIR_KEYWORDS transcriptionregulation 3 6.0 0.9213561238557244 948427,947466,947030 50 279 3389 0.7288172043010753 1.0 0.9999657512225775 99.99999999991866 GOTERM_BP_FAT GO:0006355~regulationoftranscription,DNA-dependent 3 6.0 0.9308984741108364 948427,947466,947030 35 277 2287 0.7076843733883446 1.0 0.9999999979040264 99.99999999999935 GOTERM_BP_FAT GO:0051252~regulationofRNAmetabolicprocess 3 6.0 0.9318361437984097 948427,947466,947030 35 278 2287 0.7051387461459404 1.0 0.9999999956301008 99.99999999999945 GOTERM_BP_FAT GO:0006350~transcription 3 6.0 0.9483122063390306 948427,947466,947030 35 298 2287 0.6578139980824544 1.0 0.9999999985935982 99.99999999999997 SP_PIR_KEYWORDS dna-binding 3 6.0 0.9620982560370278 948427,947466,947030 50 335 3389 0.6069850746268657 1.0 0.9999948404455522 99.99999999999997 GOTERM_MF_FAT GO:0003677~DNAbinding 3 6.0 0.9934134514824332 948427,947466,947030 35 408 2145 0.45063025210084034 1.0 0.9999999999999992 100.0