Annotation Cluster 1 Enrichment Score: 2.3744537442645512 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0046914~transitionmetalionbinding 15 30.0 0.000861066513072615 947736,948335,947527,945173,945181,948507,944988,948315,946330,945279,946036,947018,946038,948426,948758 33 443 2381 2.4430535604350503 0.08411697027291554 0.08411697027291554 0.9551131235308596 GOTERM_MF_FAT GO:0046872~metalionbinding 16 32.0 0.00544223552558342 947736,948335,947527,945173,945181,948540,948507,944988,948315,946330,945279,946036,947018,946038,948426,948758 33 593 2381 1.9467525167356534 0.4268592989060441 0.24293943366864246 5.8984832740707756 SP_PIR_KEYWORDS metal-binding 13 26.0 0.006045385819511652 947736,948335,947527,945173,944988,948315,946330,945279,946036,947018,946038,948426,948758 48 442 3802 2.329656862745098 0.43446942389769383 0.43446942389769383 6.435437245751419 GOTERM_MF_FAT GO:0043169~cationbinding 16 32.0 0.0067702035416385125 947736,948335,947527,945173,945181,948540,948507,944988,948315,946330,945279,946036,947018,946038,948426,948758 33 606 2381 1.9049904990499051 0.49988088770270356 0.20623645269136825 7.288850053957319 GOTERM_MF_FAT GO:0043167~ionbinding 16 32.0 0.0069966717156730515 947736,948335,947527,945173,945181,948540,948507,944988,948315,946330,945279,946036,947018,946038,948426,948758 33 608 2381 1.8987240829346093 0.5113793444070873 0.16392939314119725 7.524084407782006 Annotation Cluster 2 Enrichment Score: 1.0989687481477195 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS periplasm 6 12.0 0.0407907544363037 947736,948315,945492,948737,948507,948758 48 155 3802 3.0661290322580648 0.980054015414548 0.8587697462104806 36.67261840987995 GOTERM_CC_FAT GO:0042597~periplasmicspace 6 12.0 0.07208298007866432 947736,948315,945492,948737,948507,948758 21 180 1553 2.465079365079365 0.9323404564415831 0.9323404564415831 48.68965616098595 SP_PIR_KEYWORDS signal 10 20.0 0.11128089400651676 947452,947736,948315,945492,948737,945356,946006,946363,948507,948758 48 464 3802 1.7070761494252875 0.9999847291016255 0.7948929183751425 72.58725938453347 UP_SEQ_FEATURE signalpeptide 10 20.0 0.12283154951952849 947452,947736,948315,945492,948737,945356,946006,946363,948507,948758 48 464 3722 1.6711566091954022 0.9999987959839035 0.9999987959839035 76.90086536335752 Annotation Cluster 3 Enrichment Score: 0.9209829670246698 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0055114~oxidationreduction 10 20.0 0.039352352558456365 944988,947736,946169,946036,947580,946038,947018,946702,947707,948758 32 394 2550 2.02252538071066 0.9901173319839606 0.9901173319839606 36.70182635011648 GOTERM_BP_FAT GO:0006091~generationofprecursormetabolitesandenergy 8 16.0 0.03977837214155616 944988,946169,946036,947580,946038,946702,948540,948758 32 271 2550 2.3523985239852396 0.9906088100017825 0.9030918476173573 37.020841262092574 GOTERM_BP_FAT GO:0015980~energyderivationbyoxidationoforganiccompounds 6 12.0 0.07725509146596576 944988,946036,947580,946038,946702,948540 32 191 2550 2.5032722513089003 0.9999035303687834 0.9541368859530429 59.982342181933134 SP_PIR_KEYWORDS nad 5 10.0 0.0803079986582907 944988,946036,947580,946038,947018 48 133 3802 2.9777568922305764 0.9996177156816245 0.8601712031461408 60.08268873829691 GOTERM_BP_FAT GO:0045333~cellularrespiration 5 10.0 0.1455062652883632 946036,947580,946038,946702,948540 32 169 2550 2.3576183431952664 0.99999998598731 0.9731277331676508 83.32335799781745 SP_PIR_KEYWORDS oxidoreductase 8 16.0 0.15927196013884104 944988,947736,946036,947580,946038,947018,946702,947707 48 365 3802 1.7360730593607305 0.9999999172781904 0.8366688981673203 85.08993351764055 GOTERM_BP_FAT GO:0009060~aerobicrespiration 3 6.0 0.19058671306513997 947580,946702,948540 32 66 2550 3.622159090909091 0.9999999999724838 0.9826247400315408 91.0053280522256 SP_PIR_KEYWORDS metalloprotein 3 6.0 0.2461826977756468 944988,946036,947018 48 77 3802 3.0860389610389607 0.9999999999970959 0.890708984378895 95.49574672065104 GOTERM_BP_FAT GO:0009061~anaerobicrespiration 3 6.0 0.4869434298601795 946036,947580,946038 32 133 2550 1.7974624060150377 1.0 0.9998020497671314 99.95004874569725 Annotation Cluster 4 Enrichment Score: 0.8647591995414954 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0055114~oxidationreduction 10 20.0 0.039352352558456365 944988,947736,946169,946036,947580,946038,947018,946702,947707,948758 32 394 2550 2.02252538071066 0.9901173319839606 0.9901173319839606 36.70182635011648 GOTERM_BP_FAT GO:0006091~generationofprecursormetabolitesandenergy 8 16.0 0.03977837214155616 944988,946169,946036,947580,946038,946702,948540,948758 32 271 2550 2.3523985239852396 0.9906088100017825 0.9030918476173573 37.020841262092574 GOTERM_BP_FAT GO:0022900~electrontransportchain 4 8.0 0.11931703035650441 946169,947580,946038,948758 32 100 2550 3.1875 0.9999995489197725 0.9740842699369677 76.47929565686287 SP_PIR_KEYWORDS electrontransport 3 6.0 0.30164279799311444 946169,946038,948758 48 89 3802 2.6699438202247188 0.9999999999999978 0.8945888878500876 98.05218001676799 SP_PIR_KEYWORDS transport 7 14.000000000000002 0.8421528040988574 949044,946169,947580,946038,945181,947018,948758 48 653 3802 0.8490939254721797 1.0 0.9994712760883534 99.99999983976855 Annotation Cluster 5 Enrichment Score: 0.7850816486303438 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS heme 3 6.0 0.07225150045797558 946038,947018,948758 48 36 3802 6.600694444444445 0.9991321503364832 0.9046146890518295 56.074816274159204 SP_PIR_KEYWORDS iron 6 12.0 0.09212562341778993 945279,947527,946038,945181,947018,948758 48 196 3802 2.424744897959184 0.9998866500478325 0.7800096873848206 65.36244322210537 GOTERM_MF_FAT GO:0005506~ironionbinding 6 12.0 0.1291383389847978 945279,947527,946038,945181,947018,948758 33 202 2381 2.1431143114311433 0.9999992504243091 0.9046905604832018 78.57156950935087 SP_PIR_KEYWORDS transport 7 14.000000000000002 0.8421528040988574 949044,946169,947580,946038,945181,947018,948758 48 653 3802 0.8490939254721797 1.0 0.9994712760883534 99.99999983976855 Annotation Cluster 6 Enrichment Score: 0.7488630736827891 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS FAD 3 6.0 0.14730825790952767 947018,946702,947707 48 55 3802 4.320454545454545 0.9999996877852874 0.8462529928306813 82.59008806493095 SP_PIR_KEYWORDS oxidoreductase 8 16.0 0.15927196013884104 944988,947736,946036,947580,946038,947018,946702,947707 48 365 3802 1.7360730593607305 0.9999999172781904 0.8366688981673203 85.08993351764055 SP_PIR_KEYWORDS Flavoprotein 3 6.0 0.24157075717024165 947018,946702,947707 48 76 3802 3.1266447368421053 0.9999999999948476 0.9058501381114351 95.1840530932066 Annotation Cluster 7 Enrichment Score: 0.49660298537497133 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY ece02020:Two-componentsystem 3 6.0 0.2802140908143932 946611,946038,948507 15 93 1249 2.686021505376344 1.0 1.0 98.70921711181533 KEGG_PATHWAY ecc02020:Two-componentsystem 3 6.0 0.28883604189021506 946611,946038,948507 15 95 1249 2.6294736842105264 1.0 1.0 98.89943781448034 KEGG_PATHWAY ecv02020:Two-componentsystem 3 6.0 0.28883604189021506 946611,946038,948507 15 95 1249 2.6294736842105264 1.0 1.0 98.89943781448034 KEGG_PATHWAY ecw02020:Two-componentsystem 3 6.0 0.3017718739032617 946611,946038,948507 15 98 1249 2.548979591836735 1.0 0.9999999999999976 99.13673784235803 KEGG_PATHWAY eck02020:Two-componentsystem 3 6.0 0.3060825536369795 946611,946038,948507 15 99 1249 2.5232323232323233 1.0 0.9999999999928899 99.20464468741092 KEGG_PATHWAY eci02020:Two-componentsystem 3 6.0 0.3060825536369795 946611,946038,948507 15 99 1249 2.5232323232323233 1.0 0.9999999999928899 99.20464468741092 KEGG_PATHWAY ect02020:Two-componentsystem 3 6.0 0.3103917799027805 946611,946038,948507 15 100 1249 2.498 1.0 0.9999999991499263 99.26756337437872 KEGG_PATHWAY ecz02020:Two-componentsystem 3 6.0 0.31469907413624254 946611,946038,948507 15 101 1249 2.4732673267326737 1.0 0.9999999794043698 99.32582791818545 KEGG_PATHWAY ecf02020:Two-componentsystem 3 6.0 0.31900396709118267 946611,946038,948507 15 102 1249 2.449019607843137 1.0 0.9999997995773544 99.37975288243426 KEGG_PATHWAY ecr02020:Two-componentsystem 3 6.0 0.31900396709118267 946611,946038,948507 15 102 1249 2.449019607843137 1.0 0.9999997995773544 99.37975288243426 KEGG_PATHWAY ecq02020:Two-componentsystem 3 6.0 0.31900396709118267 946611,946038,948507 15 102 1249 2.449019607843137 1.0 0.9999997995773544 99.37975288243426 KEGG_PATHWAY eum02020:Two-componentsystem 3 6.0 0.3233059987141104 946611,946038,948507 15 103 1249 2.425242718446602 1.0 0.9999988971143865 99.42963425121833 KEGG_PATHWAY ecm02020:Two-componentsystem 3 6.0 0.3276047180243713 946611,946038,948507 15 104 1249 2.401923076923077 1.0 0.9999958498982071 99.47575028605591 KEGG_PATHWAY ecx02020:Two-componentsystem 3 6.0 0.3276047180243713 946611,946038,948507 15 104 1249 2.401923076923077 1.0 0.9999958498982071 99.47575028605591 KEGG_PATHWAY ecd02020:Two-componentsystem 3 6.0 0.331899682994488 946611,946038,948507 15 105 1249 2.3790476190476193 1.0 0.999988031185205 99.51836236549626 KEGG_PATHWAY ecg02020:Two-componentsystem 3 6.0 0.3361904604311875 946611,946038,948507 15 106 1249 2.3566037735849057 1.0 0.9999715540759708 99.55771580537935 KEGG_PATHWAY ecj02020:Two-componentsystem 3 6.0 0.37455176552732117 946611,946038,948507 15 115 1249 2.1721739130434785 1.0 0.9999831157696287 99.79877242699793 KEGG_PATHWAY eco02020:Two-componentsystem 3 6.0 0.3787787032042904 946611,946038,948507 15 116 1249 2.153448275862069 1.0 0.9999660421622545 99.81603899714044 Annotation Cluster 8 Enrichment Score: 0.2672039359827283 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS dna-binding 7 14.000000000000002 0.2873746984004231 946091,945279,948800,947560,948426,945473,947613 48 362 3802 1.5316528545119705 0.9999999999999852 0.897182199041426 97.5683326312827 SP_PIR_KEYWORDS transcriptionregulation 6 12.0 0.3040319253100866 946091,945279,945173,948800,945473,947613 48 297 3802 1.6001683501683501 0.9999999999999984 0.8810916796729318 98.12404527499366 SP_PIR_KEYWORDS activator 3 6.0 0.31085867100195824 946091,945279,947613 48 91 3802 2.6112637362637363 0.9999999999999993 0.8723737554551215 98.31631820130417 SP_PIR_KEYWORDS Transcription 5 10.0 0.5091405682643129 946091,945279,948800,945473,947613 48 298 3802 1.3289988814317675 1.0 0.9704163936484759 99.95927751712247 GOTERM_BP_FAT GO:0006350~transcription 5 10.0 0.5630612866812402 946091,945279,948800,945473,947613 32 322 2550 1.2373835403726707 1.0 0.9999267452074717 99.99198142502907 GOTERM_MF_FAT GO:0003677~DNAbinding 7 14.000000000000002 0.5663050143396884 946091,945279,948800,947560,948426,945473,947613 33 444 2381 1.1375238875238876 1.0 0.9999948327626205 99.99092238073418 SP_PIR_KEYWORDS DNAbinding 3 6.0 0.5705629718506942 946091,948426,947613 48 153 3802 1.5531045751633987 1.0 0.9811796542822362 99.99060388598423 GOTERM_BP_FAT GO:0045449~regulationoftranscription 5 10.0 0.6013311124584847 946091,945279,948800,945473,947613 32 337 2550 1.182307121661721 1.0 0.9999332296582267 99.99717739817213 GOTERM_BP_FAT GO:0006355~regulationoftranscription,DNA-dependent 4 8.0 0.697618172292283 946091,945279,945473,947613 32 288 2550 1.1067708333333333 1.0 0.9999745952047377 99.99987891046537 GOTERM_BP_FAT GO:0051252~regulationofRNAmetabolicprocess 4 8.0 0.697618172292283 946091,945279,945473,947613 32 288 2550 1.1067708333333333 1.0 0.9999745952047377 99.99987891046537 UP_SEQ_FEATURE DNA-bindingregion:H-T-Hmotif 3 6.0 0.7283017841951707 945279,948800,947613 48 200 3722 1.163125 1.0 1.0 99.99995297034478 GOTERM_MF_FAT GO:0003700~transcriptionfactoractivity 3 6.0 0.7382959229123558 945279,945473,947613 33 190 2381 1.1392344497607656 1.0 0.9999960050123652 99.9999673421188 GOTERM_MF_FAT GO:0030528~transcriptionregulatoractivity 3 6.0 0.8487497852514359 945279,945473,947613 33 240 2381 0.9018939393939394 1.0 0.9999941039385707 99.99999992735253 Annotation Cluster 9 Enrichment Score: 0.15683045925061767 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0015980~energyderivationbyoxidationoforganiccompounds 6 12.0 0.07725509146596576 944988,946036,947580,946038,946702,948540 32 191 2550 2.5032722513089003 0.9999035303687834 0.9541368859530429 59.982342181933134 GOTERM_BP_FAT GO:0045333~cellularrespiration 5 10.0 0.1455062652883632 946036,947580,946038,946702,948540 32 169 2550 2.3576183431952664 0.99999998598731 0.9731277331676508 83.32335799781745 GOTERM_BP_FAT GO:0006796~phosphatemetabolicprocess 3 6.0 0.19503131742650748 946611,947580,946971 32 67 2550 3.568097014925373 0.9999999999853922 0.9716806477673413 91.55215446336449 GOTERM_BP_FAT GO:0006793~phosphorusmetabolicprocess 3 6.0 0.3132213048108259 946611,947580,946971 32 93 2550 2.5705645161290325 1.0 0.9954893232478992 98.61576211195163 UP_SEQ_FEATURE transmembraneregion 8 16.0 0.8976285548165288 949044,946611,947580,946038,946381,946981,948540,946311 48 789 3722 0.786227291930714 1.0 1.0 99.99999999914387 SP_PIR_KEYWORDS transmembrane 8 16.0 0.9050010079469115 949044,946611,947580,946038,946381,946981,948540,946311 48 816 3802 0.7765522875816994 1.0 0.9999009017299283 99.99999999938949 UP_SEQ_FEATURE topologicaldomain:Cytoplasmic 5 10.0 0.9102109528393869 946611,947580,946038,946381,948540 48 519 3722 0.747029543994862 1.0 1.0 99.99999999980244 UP_SEQ_FEATURE topologicaldomain:Periplasmic 5 10.0 0.9118178216511458 946611,947580,946038,946381,948540 48 521 3722 0.7441618682021753 1.0 0.9999999999999998 99.99999999983856 SP_PIR_KEYWORDS transmembraneprotein 3 6.0 0.9505247366352445 947580,946038,946311 48 368 3802 0.6457201086956522 1.0 0.99998767181022 99.99999999999952 SP_PIR_KEYWORDS membrane 9 18.0 0.9606404231968804 949044,946611,947580,946038,946381,946981,946971,948540,946311 48 1021 3802 0.6982125367286974 1.0 0.9999916714978178 99.99999999999997 SP_PIR_KEYWORDS cellinnermembrane 6 12.0 0.9639910248588346 946611,947580,946038,946381,946971,948540 48 734 3802 0.6474795640326976 1.0 0.9999905773990813 99.99999999999999 GOTERM_CC_FAT GO:0016021~integraltomembrane 8 16.0 0.9686720714614983 949044,946611,947580,946038,946381,946981,948540,946311 21 824 1553 0.7179842810910771 1.0 0.9999999999999709 99.99999999999616 SP_PIR_KEYWORDS cellmembrane 8 16.0 0.9731655727794931 949044,946611,947580,946038,946381,946971,948540,946311 48 968 3802 0.6546143250688705 1.0 0.999994692430639 100.0 GOTERM_CC_FAT GO:0019866~organelleinnermembrane 4 8.0 0.9804437957615257 946611,947580,946038,948540 21 508 1553 0.582302212223472 1.0 0.999999999999502 99.99999999999994 GOTERM_CC_FAT GO:0031967~organelleenvelope 4 8.0 0.9804437957615257 946611,947580,946038,948540 21 508 1553 0.582302212223472 1.0 0.999999999999502 99.99999999999994 GOTERM_CC_FAT GO:0031090~organellemembrane 4 8.0 0.9807166049596672 946611,947580,946038,948540 21 509 1553 0.5811582000187108 1.0 0.9999999999485837 99.99999999999994 GOTERM_CC_FAT GO:0031224~intrinsictomembrane 8 16.0 0.9887157892179425 949044,946611,947580,946038,946381,946981,948540,946311 21 895 1553 0.6610268688480979 1.0 0.9999999999035866 100.0 GOTERM_CC_FAT GO:0005886~plasmamembrane 8 16.0 0.9968923961365829 949044,946611,947580,946038,946381,946971,948540,946311 21 970 1553 0.6099165439371624 1.0 0.999999999994801 100.0 GOTERM_CC_FAT GO:0031975~envelope 4 8.0 0.9974927596541173 946611,947580,946038,948540 21 640 1553 0.462202380952381 1.0 0.999999999960483 100.0 GOTERM_CC_FAT GO:0009274~peptidoglycan-basedcellwall 4 8.0 0.9981668296636911 946611,947580,946038,948540 21 658 1553 0.44955854682298446 1.0 0.9999999998595472 100.0 GOTERM_CC_FAT GO:0005618~cellwall 4 8.0 0.9982304419410806 946611,947580,946038,948540 21 660 1553 0.4481962481962482 1.0 0.9999999990159614 100.0 GOTERM_CC_FAT GO:0030312~externalencapsulatingstructure 4 8.0 0.9994392879756301 946611,947580,946038,948540 21 722 1553 0.4097084817306424 1.0 0.9999999998237132 100.0 Annotation Cluster 10 Enrichment Score: 0.11391427274189507 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS atp-binding 5 10.0 0.6806048634399446 946611,946971,946006,947287,948426 48 368 3802 1.0762001811594204 1.0 0.9939566318427117 99.99963479505845 GOTERM_MF_FAT GO:0030554~adenylnucleotidebinding 6 12.0 0.7135891640255704 946611,946971,946006,947707,947287,948426 33 431 2381 1.004429445264712 1.0 0.9999992987378876 99.99991077842219 GOTERM_MF_FAT GO:0001883~purinenucleosidebinding 6 12.0 0.7135891640255704 946611,946971,946006,947707,947287,948426 33 431 2381 1.004429445264712 1.0 0.9999992987378876 99.99991077842219 GOTERM_MF_FAT GO:0001882~nucleosidebinding 6 12.0 0.725858555224236 946611,946971,946006,947707,947287,948426 33 437 2381 0.9906386519658831 1.0 0.9999981492749127 99.99994521875912 UP_SEQ_FEATURE nucleotidephosphate-bindingregion:ATP 3 6.0 0.7435423770783949 946006,947287,948426 48 206 3722 1.129247572815534 1.0 1.0 99.99997533709445 SP_PIR_KEYWORDS nucleotide-binding 5 10.0 0.7497591038484237 946611,946971,946006,947287,948426 48 403 3802 0.9827336641852772 1.0 0.9973124964722775 99.99997487781471 GOTERM_MF_FAT GO:0017076~purinenucleotidebinding 6 12.0 0.7749921081154889 946611,946971,946006,947707,947287,948426 33 463 2381 0.9350088356567838 1.0 0.9999968834013279 99.99999393243165 GOTERM_MF_FAT GO:0005524~ATPbinding 5 10.0 0.7924450296407655 946611,946971,946006,947287,948426 33 389 2381 0.9273973669860559 1.0 0.9999956134655538 99.9999975318614 GOTERM_MF_FAT GO:0032559~adenylribonucleotidebinding 5 10.0 0.7942237336503245 946611,946971,946006,947287,948426 33 390 2381 0.9250194250194251 1.0 0.9999900552423299 99.99999775752744 GOTERM_MF_FAT GO:0032553~ribonucleotidebinding 5 10.0 0.8452765009999881 946611,946971,946006,947287,948426 33 422 2381 0.8548757719373834 1.0 0.9999969169349229 99.99999990644412 GOTERM_MF_FAT GO:0032555~purineribonucleotidebinding 5 10.0 0.8452765009999881 946611,946971,946006,947287,948426 33 422 2381 0.8548757719373834 1.0 0.9999969169349229 99.99999990644412 GOTERM_MF_FAT GO:0000166~nucleotidebinding 6 12.0 0.878923010587785 946611,946971,946006,947707,947287,948426 33 536 2381 0.8076662143826323 1.0 0.9999968495711059 99.99999999390963