Annotation Cluster 1 Enrichment Score: 1.352577042775152 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS cellmembrane 26 52.0 0.00010057771288601421 948065,945156,945668,945841,947966,948579,947011,947013,945995,945936,946350,947333,945775,947235,945679,1450286,944820,946146,948946,945361,944967,946601,945863,946028,947652,947040 48 727 2707 2.016907381934892 0.01000786181898361 0.01000786181898361 0.11157801235354148 SP_PIR_KEYWORDS membrane 26 52.0 0.0002697038036113943 948065,945156,945668,945841,947966,948579,947011,947013,945995,945936,946350,947333,945775,947235,945679,1450286,944820,946146,948946,945361,944967,946601,945863,946028,947652,947040 48 769 2707 1.906751192024274 0.02661346829704392 0.013396466810017937 0.2989462465531667 SP_PIR_KEYWORDS cellinnermembrane 19 38.0 0.003360446018105932 948065,945156,947235,945679,945841,947966,948579,946146,948946,947011,945361,945863,947013,946601,946028,945995,947040,947652,947333 48 552 2707 1.9411609299516908 0.28581303831354377 0.10613766194090668 3.66722352401202 SP_PIR_KEYWORDS transmembrane 20 40.0 0.005490057901825546 945156,947235,1450286,945679,945841,944820,947966,948579,945361,944967,945863,947013,946601,946028,945995,945936,946350,947040,947652,947333 48 624 2707 1.8075587606837606 0.42334918305086755 0.12857858604048766 5.927454728405868 UP_SEQ_FEATURE transmembraneregion 19 38.0 0.006456250365597456 945156,947235,1450286,945679,945841,947966,948579,945361,944967,945863,947013,946601,946028,945995,945936,946350,947040,947652,947333 46 600 2646 1.8215217391304348 0.5801855287278722 0.5801855287278722 7.3032541624243 GOTERM_CC_FAT GO:0005886~plasmamembrane 26 52.0 0.00902681519124875 948065,945156,945668,945841,947966,948579,947011,947013,945995,945936,946350,947333,945775,947235,945679,1450286,944820,946146,948946,945361,944967,946601,945863,946028,947652,947040 30 729 1124 1.3362597165066301 0.1882472546358387 0.1882472546358387 6.935251283429212 GOTERM_CC_FAT GO:0031224~intrinsictomembrane 24 48.0 0.027297277672825776 945156,945775,947235,945668,1450286,945841,945679,944820,947966,948579,947011,948946,945361,944967,945863,947013,946601,946028,945995,945936,946350,947040,947652,947333 30 684 1124 1.3146198830409357 0.4708935923612123 0.27260299173093394 19.69803976809984 SP_PIR_KEYWORDS transmembraneprotein 9 18.0 0.07826893496991591 947966,945361,945863,946601,946028,945841,945679,947333,947040 48 262 2707 1.9372614503816794 0.9997113161603883 0.6878624138225102 59.53029754216123 UP_SEQ_FEATURE topologicaldomain:Cytoplasmic 11 22.0 0.11201777194648714 945156,945361,946601,945995,946028,947235,945841,945679,947333,947652,947040 46 388 2646 1.6307709547288212 0.9999998780525536 0.9950410365936521 75.11706848086234 UP_SEQ_FEATURE topologicaldomain:Periplasmic 11 22.0 0.11647023791152447 945156,945361,944967,946601,945995,946028,947235,945679,947333,947652,947040 46 391 2646 1.6182586456132548 0.9999999378217367 0.9842089995139117 76.53928428271128 GOTERM_CC_FAT GO:0016021~integraltomembrane 20 40.0 0.1981154689507366 945156,947235,1450286,945679,945841,944820,947966,948579,945361,944967,945863,947013,946601,946028,945995,945936,946350,947040,947652,947333 30 630 1124 1.1894179894179893 0.9937687923942452 0.719040930933108 82.6237716727324 GOTERM_CC_FAT GO:0019866~organelleinnermembrane 12 24.0 0.34085392398291103 944820,947966,948579,947011,945361,945863,946601,945995,946028,947235,945841,947040 30 369 1124 1.2184281842818427 0.9999313598169175 0.7457707650980269 96.32563031482444 GOTERM_CC_FAT GO:0031967~organelleenvelope 12 24.0 0.34085392398291103 944820,947966,948579,947011,945361,945863,946601,945995,946028,947235,945841,947040 30 369 1124 1.2184281842818427 0.9999313598169175 0.7457707650980269 96.32563031482444 GOTERM_CC_FAT GO:0031090~organellemembrane 12 24.0 0.34471879498255065 944820,947966,948579,947011,945361,945863,946601,945995,946028,947235,945841,947040 30 370 1124 1.2151351351351352 0.9999400433490694 0.7033600284964456 96.49297196720894 GOTERM_CC_FAT GO:0031975~envelope 14 28.000000000000004 0.4435403414588932 945775,947235,945841,947966,944820,948579,947011,945361,944967,946601,945863,945995,946028,947040 30 471 1124 1.113658881811748 0.9999986037128118 0.7402847356687638 99.04012485444426 GOTERM_CC_FAT GO:0009274~peptidoglycan-basedcellwall 14 28.000000000000004 0.4829080298302173 945156,945775,947235,947966,944820,948579,947011,945361,944967,946601,945863,946028,947043,947040 30 481 1124 1.0905058905058906 0.9999997417387456 0.7481764766478287 99.46342047516775 GOTERM_CC_FAT GO:0005618~cellwall 14 28.000000000000004 0.48685228682216364 945156,945775,947235,947966,944820,948579,947011,945361,944967,946601,945863,946028,947043,947040 30 482 1124 1.0882434301521438 0.9999997834415422 0.6928489992797662 99.49501811587443 GOTERM_CC_FAT GO:0030312~externalencapsulatingstructure 14 28.000000000000004 0.6695920246235155 945156,945775,947235,947966,944820,948579,947011,945361,944967,946601,945863,946028,947043,947040 30 530 1124 0.989685534591195 0.9999999999913272 0.7964668636003571 99.98458940485013 Annotation Cluster 2 Enrichment Score: 0.9123825767674666 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR KEGG_PATHWAY ecr02010:ABCtransporters 5 10.0 0.06373424530163228 947966,948065,945361,946028,947235 15 97 855 2.938144329896907 0.9999998539861162 0.9999998539861162 57.23595948936546 KEGG_PATHWAY ect02010:ABCtransporters 5 10.0 0.07001600747071379 947966,948065,945361,946028,947235 15 100 855 2.85 0.9999999707828324 0.9998290696997431 60.79273946064318 KEGG_PATHWAY eum02010:ABCtransporters 5 10.0 0.07218362465347097 947966,948065,945361,946028,947235 15 101 855 2.8217821782178216 0.999999983272696 0.9974425411779327 61.95529858220203 KEGG_PATHWAY ecp02010:ABCtransporters 3 6.0 0.07382622006058258 947966,948065,945361 15 28 855 6.107142857142857 0.9999999890477543 0.9897699962113267 62.815001298881754 KEGG_PATHWAY ecs02010:ABCtransporters 3 6.0 0.07382622006058258 947966,948065,945361 15 28 855 6.107142857142857 0.9999999890477543 0.9897699962113267 62.815001298881754 KEGG_PATHWAY eck02010:ABCtransporters 5 10.0 0.07438796917775273 947966,948065,945361,946028,947235 15 102 855 2.7941176470588234 0.9999999905260999 0.9751511805467842 63.10487294376127 KEGG_PATHWAY ecy02010:ABCtransporters 3 6.0 0.07855848535903956 947966,948065,945361 15 29 855 5.8965517241379315 0.9999999967804273 0.9615733043889891 65.19261687004476 KEGG_PATHWAY ecd02010:ABCtransporters 5 10.0 0.08595703838756 947966,948065,945361,946028,947235 15 107 855 2.6635514018691584 0.9999999995311656 0.9535176045816596 68.63032768554824 KEGG_PATHWAY ecl02010:ABCtransporters 3 6.0 0.08831250094999618 947966,948065,945361 15 31 855 5.516129032258065 0.9999999997469572 0.9368462351925673 69.65722506669476 KEGG_PATHWAY ecj02010:ABCtransporters 5 10.0 0.10102583248951752 947966,948065,945361,946028,947235 15 113 855 2.5221238938053094 0.9999999999911776 0.9408803948372998 74.68445396548795 KEGG_PATHWAY eco02010:ABCtransporters 5 10.0 0.10366065135193737 947966,948065,945361,946028,947235 15 114 855 2.5 0.9999999999956256 0.9268706281382639 75.62501528910288 INTERPRO IPR000515:Binding-protein-dependenttransportsystemsinnermembranecomponent 3 6.0 0.11917313321791705 945361,946028,947235 41 37 2474 4.892551087673039 0.9999981438310502 0.9999981438310502 75.80049875627793 UP_SEQ_FEATURE domain:ABCtransmembranetype-1 3 6.0 0.141225763592444 945361,946028,947235 46 39 2646 4.424749163879598 0.9999999986202928 0.9830972493026169 83.17963949860766 KEGG_PATHWAY ecx02010:ABCtransporters 4 8.0 0.1589530094469312 947966,948065,945361,947235 15 86 855 2.6511627906976742 1.0 0.9767432346742342 89.27839474602827 KEGG_PATHWAY ecf02010:ABCtransporters 4 8.0 0.16711438550647428 947966,948065,945361,947235 15 88 855 2.590909090909091 1.0 0.9737985631626423 90.54559894698073 KEGG_PATHWAY ecw02010:ABCtransporters 4 8.0 0.17124826018593775 947966,948065,945361,947235 15 89 855 2.561797752808989 1.0 0.9683579256901078 91.1333296263052 KEGG_PATHWAY ecm02010:ABCtransporters 4 8.0 0.17541643804843582 947966,948065,945361,947235 15 90 855 2.5333333333333337 1.0 0.962845946534434 91.69165191503795 KEGG_PATHWAY ece02010:ABCtransporters 4 8.0 0.17961805049256155 947966,948065,945361,947235 15 91 855 2.5054945054945055 1.0 0.9573430500161192 92.22147308086073 KEGG_PATHWAY ecc02010:ABCtransporters 4 8.0 0.18811809732988863 947966,948065,945361,947235 15 93 855 2.4516129032258065 1.0 0.9555317940209884 93.19931996524727 KEGG_PATHWAY eci02010:ABCtransporters 4 8.0 0.1924147884710462 947966,948065,945361,947235 15 94 855 2.425531914893617 1.0 0.9504347275832343 93.64922605179646 KEGG_PATHWAY ecz02010:ABCtransporters 4 8.0 0.20109714551795846 947966,948065,945361,947235 15 96 855 2.375 1.0 0.9492616149307833 94.47574152446056 KEGG_PATHWAY ecq02010:ABCtransporters 4 8.0 0.20109714551795846 947966,948065,945361,947235 15 96 855 2.375 1.0 0.9492616149307833 94.47574152446056 KEGG_PATHWAY ecv02010:ABCtransporters 4 8.0 0.20109714551795846 947966,948065,945361,947235 15 96 855 2.375 1.0 0.9492616149307833 94.47574152446056 KEGG_PATHWAY ecg02010:ABCtransporters 4 8.0 0.21879336865694873 947966,948065,945361,947235 15 100 855 2.2800000000000002 1.0 0.9552175173397905 95.86198296675525 Annotation Cluster 3 Enrichment Score: 0.7070642842997659 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS proteintransport 3 6.0 0.11096339529786811 948065,945775,946028 48 33 2707 5.1268939393939394 0.9999922023403743 0.7701229928614894 72.89550033505351 GOTERM_BP_FAT GO:0008104~proteinlocalization 3 6.0 0.237422045298975 948065,945775,946028 30 57 1779 3.1210526315789475 0.9999999999999999 0.9999999886711295 95.83193042851399 GOTERM_BP_FAT GO:0015031~proteintransport 3 6.0 0.237422045298975 948065,945775,946028 30 57 1779 3.1210526315789475 0.9999999999999999 0.9999999886711295 95.83193042851399 GOTERM_BP_FAT GO:0045184~establishmentofproteinlocalization 3 6.0 0.237422045298975 948065,945775,946028 30 57 1779 3.1210526315789475 0.9999999999999999 0.9999999886711295 95.83193042851399 Annotation Cluster 4 Enrichment Score: 0.7011718632099203 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0031225~anchoredtomembrane 5 10.0 0.05773272985270709 945775,947011,948946,945668,1450286 30 58 1124 3.229885057471264 0.7453143712164115 0.3661281288162799 37.584196413704085 UP_SEQ_FEATURE lipidmoiety-bindingregion:S-diacylglycerolcysteine 3 6.0 0.2526671491414142 945775,947011,945668 46 57 2646 3.0274599542334095 1.0 0.9985032556275826 96.69581548069625 UP_SEQ_FEATURE lipidmoiety-bindingregion:N-palmitoylcysteine 3 6.0 0.2526671491414142 945775,947011,945668 46 57 2646 3.0274599542334095 1.0 0.9985032556275826 96.69581548069625 SP_PIR_KEYWORDS palmitate 3 6.0 0.26026941435939344 945775,947011,945668 48 57 2707 2.968201754385965 0.9999999999999192 0.9509390720302596 96.47789580550975 SP_PIR_KEYWORDS lipoprotein 3 6.0 0.3252354639713897 945775,947011,945668 48 67 2707 2.5251865671641793 1.0 0.9720205851340535 98.73029875698168 Annotation Cluster 5 Enrichment Score: 0.5957568221350925 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS celloutermembrane 4 8.0 0.057175346121762276 944820,945775,944967,945863 48 51 2707 4.423202614379084 0.9972260857301602 0.691951848593114 47.976445024363066 GOTERM_CC_FAT GO:0009279~celloutermembrane 4 8.0 0.26825497633882084 944820,945775,944967,945863 30 70 1124 2.1409523809523807 0.9992409421332958 0.7622858811361924 91.58863970359312 GOTERM_CC_FAT GO:0019867~outermembrane 4 8.0 0.28269724880172 944820,945775,944967,945863 30 72 1124 2.0814814814814815 0.9995200926283442 0.7201923589259334 92.81799875767099 GOTERM_CC_FAT GO:0030313~cellenvelope 5 10.0 0.48549436042669203 944820,945775,944967,945863,947235 30 138 1124 1.357487922705314 0.9999997698700155 0.7202107006636533 99.48432839683502 GOTERM_CC_FAT GO:0044462~externalencapsulatingstructurepart 4 8.0 0.49883110718431817 944820,945775,944967,945863 30 102 1124 1.4692810457516339 0.9999998742133772 0.6785475449927563 99.58124032824497 Annotation Cluster 6 Enrichment Score: 0.1393497137027263 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0008652~cellularaminoacidbiosyntheticprocess 3 6.0 0.6252456245284932 947966,947235,948278 30 127 1779 1.4007874015748032 1.0 0.9999999997433738 99.99899369130267 GOTERM_BP_FAT GO:0009309~aminebiosyntheticprocess 3 6.0 0.6835207196678064 947966,947235,948278 30 141 1779 1.2617021276595746 1.0 0.999999999768899 99.99986126234528 GOTERM_BP_FAT GO:0016053~organicacidbiosyntheticprocess 3 6.0 0.7135461406946635 947966,947235,948278 30 149 1779 1.1939597315436241 1.0 0.9999999993116684 99.99995688107029 GOTERM_BP_FAT GO:0046394~carboxylicacidbiosyntheticprocess 3 6.0 0.7135461406946635 947966,947235,948278 30 149 1779 1.1939597315436241 1.0 0.9999999993116684 99.99995688107029 GOTERM_BP_FAT GO:0044271~nitrogencompoundbiosyntheticprocess 3 6.0 0.9238574455812707 947966,947235,948278 30 244 1779 0.7290983606557377 1.0 0.9999999999999992 99.99999999999226 Annotation Cluster 7 Enrichment Score: 0.0848364160304206 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS nucleotidebinding 3 6.0 0.43190849509925805 947684,948065,948878 48 84 2707 2.0141369047619047 1.0 0.9823865283686718 99.81198025336275 SP_PIR_KEYWORDS P-loop 3 6.0 0.46171263849195127 947684,948065,948878 48 89 2707 1.9009831460674156 1.0 0.9839023967005807 99.89662081447182 SP_PIR_KEYWORDS nucleotide-binding 5 10.0 0.7403124932004759 945063,947684,948065,948878,947013 48 283 2707 0.9963928150765607 1.0 0.9996405864451517 99.9999683197098 GOTERM_MF_FAT GO:0032555~purineribonucleotidebinding 4 8.0 0.8879694506030071 947684,948065,948878,947013 28 296 1651 0.7968146718146718 1.0 1.0 99.99999999877812 GOTERM_MF_FAT GO:0032553~ribonucleotidebinding 4 8.0 0.8879694506030071 947684,948065,948878,947013 28 296 1651 0.7968146718146718 1.0 1.0 99.99999999877812 GOTERM_MF_FAT GO:0000166~nucleotidebinding 5 10.0 0.9144412267072249 945063,947684,948065,948878,947013 28 392 1651 0.7520954810495627 1.0 1.0 99.99999999994465 GOTERM_MF_FAT GO:0017076~purinenucleotidebinding 4 8.0 0.9296301307763651 947684,948065,948878,947013 28 330 1651 0.7147186147186148 1.0 1.0 99.99999999999413 SP_PIR_KEYWORDS atp-binding 3 6.0 0.9476986434813764 948065,948878,947013 48 258 2707 0.655765503875969 1.0 0.9999992099024244 99.9999999999994 GOTERM_MF_FAT GO:0005524~ATPbinding 3 6.0 0.9530390142493759 948065,948878,947013 28 273 1651 0.6479591836734693 1.0 1.0 99.99999999999994 GOTERM_MF_FAT GO:0032559~adenylribonucleotidebinding 3 6.0 0.9537877384551218 948065,948878,947013 28 274 1651 0.6455943691345151 1.0 1.0 99.99999999999996 GOTERM_MF_FAT GO:0001883~purinenucleosidebinding 3 6.0 0.9735986370344342 948065,948878,947013 28 308 1651 0.5743274582560297 1.0 1.0 100.0 GOTERM_MF_FAT GO:0030554~adenylnucleotidebinding 3 6.0 0.9735986370344342 948065,948878,947013 28 308 1651 0.5743274582560297 1.0 1.0 100.0 GOTERM_MF_FAT GO:0001882~nucleosidebinding 3 6.0 0.9765475119062867 948065,948878,947013 28 315 1651 0.5615646258503402 1.0 1.0 100.0 Annotation Cluster 8 Enrichment Score: 0.03585080354253872 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS metal-binding 4 8.0 0.8981907413675149 946146,946879,945154,945957 48 293 2707 0.7699089874857793 1.0 0.9999940044674803 99.9999999990293 GOTERM_MF_FAT GO:0046872~metalionbinding 5 10.0 0.9239219627514044 946146,945361,946879,945154,945957 28 401 1651 0.7352155325970787 1.0 1.0 99.99999999998562 GOTERM_MF_FAT GO:0043167~ionbinding 5 10.0 0.9306715980363129 946146,945361,946879,945154,945957 28 408 1651 0.7226015406162465 1.0 1.0 99.99999999999505 GOTERM_MF_FAT GO:0043169~cationbinding 5 10.0 0.9306715980363129 946146,945361,946879,945154,945957 28 408 1651 0.7226015406162465 1.0 1.0 99.99999999999505