Annotation Cluster 1 Enrichment Score: 0.29925789784516654 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_CC_FAT GO:0042597~periplasmicspace 4 8.0 0.2596565221889372 946698,945364,948261,946725 17 158 1420 2.114668652271035 0.9992648125008797 0.9992648125008797 91.0337382919522 SP_PIR_KEYWORDS periplasm 4 8.0 0.28255435718170796 946698,945364,948261,946725 49 137 3548 2.1141069566512734 0.9999999999992304 0.9999991227202594 97.16821139138798 KEGG_PATHWAY ecx02010:ABCtransporters 3 6.0 0.4774429336160446 945364,948261,948530 17 115 1169 1.7938618925831202 1.0 1.0 99.98115826492196 KEGG_PATHWAY ecf02010:ABCtransporters 3 6.0 0.4869263627296587 945364,948261,948530 17 117 1169 1.7631975867269984 1.0 1.0 99.98520864371233 KEGG_PATHWAY ecw02010:ABCtransporters 3 6.0 0.4869263627296587 945364,948261,948530 17 117 1169 1.7631975867269984 1.0 1.0 99.98520864371233 KEGG_PATHWAY ecm02010:ABCtransporters 3 6.0 0.4963189390895523 945364,948261,948530 17 119 1169 1.7335640138408306 1.0 1.0 99.98841304479866 KEGG_PATHWAY ece02010:ABCtransporters 3 6.0 0.5102324648513745 945364,948261,948530 17 122 1169 1.6909353905496625 1.0 1.0 99.99199797575655 KEGG_PATHWAY ecv02010:ABCtransporters 3 6.0 0.5102324648513745 945364,948261,948530 17 122 1169 1.6909353905496625 1.0 1.0 99.99199797575655 KEGG_PATHWAY ecc02010:ABCtransporters 3 6.0 0.5148224952940013 945364,948261,948530 17 123 1169 1.677187948350072 1.0 1.0 99.99293423754928 KEGG_PATHWAY eci02010:ABCtransporters 3 6.0 0.5193882109338095 945364,948261,948530 17 124 1169 1.6636622390891842 1.0 0.9999999999999984 99.99376416130005 KEGG_PATHWAY ecq02010:ABCtransporters 3 6.0 0.5239293814336317 945364,948261,948530 17 125 1169 1.6503529411764708 1.0 0.9999999999998578 99.99449941783875 KEGG_PATHWAY ecz02010:ABCtransporters 3 6.0 0.5239293814336317 945364,948261,948530 17 125 1169 1.6503529411764708 1.0 0.9999999999998578 99.99449941783875 KEGG_PATHWAY ecr02010:ABCtransporters 3 6.0 0.5284457862494796 945364,948261,948530 17 126 1169 1.6372549019607843 1.0 0.9999999999958845 99.99515044787066 SP_PIR_KEYWORDS signal 7 14.000000000000002 0.5341603107199859 946698,946716,945943,945364,948261,948530,946725 49 430 3548 1.178737541528239 1.0 0.999977337343098 99.97252736418952 KEGG_PATHWAY ecg02010:ABCtransporters 3 6.0 0.5462596698401696 945364,948261,948530 17 130 1169 1.5868778280542988 1.0 0.999999999977037 99.9970846564647 KEGG_PATHWAY ect02010:ABCtransporters 3 6.0 0.5462596698401696 945364,948261,948530 17 130 1169 1.5868778280542988 1.0 0.999999999977037 99.9970846564647 KEGG_PATHWAY eum02010:ABCtransporters 3 6.0 0.555012971302157 945364,948261,948530 17 132 1169 1.5628342245989304 1.0 0.9999999998455132 99.99774633200373 UP_SEQ_FEATURE signalpeptide 7 14.000000000000002 0.5571809715039127 946698,946716,945943,945364,948261,948530,946725 49 430 3470 1.1528239202657806 1.0 0.9999999999999998 99.98555628187333 KEGG_PATHWAY eck02010:ABCtransporters 3 6.0 0.5593506239947517 945364,948261,948530 17 133 1169 1.5510835913312695 1.0 0.9999999990604751 99.99801997559484 KEGG_PATHWAY ecd02010:ABCtransporters 3 6.0 0.5889732627177038 945364,948261,948530 17 140 1169 1.473529411764706 1.0 0.9999999989468767 99.99921064799156 KEGG_PATHWAY ecj02010:ABCtransporters 3 6.0 0.6172731597514416 945364,948261,948530 17 147 1169 1.4033613445378152 1.0 0.9999999988827393 99.99969249443313 KEGG_PATHWAY eco02010:ABCtransporters 3 6.0 0.6251122078245237 945364,948261,948530 17 149 1169 1.384524279510462 1.0 0.9999999967755059 99.99976607262711 Annotation Cluster 2 Enrichment Score: 0.20041154908315062 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_MF_FAT GO:0046872~metalionbinding 7 14.000000000000002 0.5560734191469745 946698,2847765,945364,945057,945181,946725,945664 25 552 2253 1.1428260869565219 1.0 1.0 99.98718116774492 GOTERM_MF_FAT GO:0043167~ionbinding 7 14.000000000000002 0.5681346851622322 946698,2847765,945364,945057,945181,946725,945664 25 558 2253 1.1305376344086022 1.0 1.0 99.99054131223052 GOTERM_MF_FAT GO:0043169~cationbinding 7 14.000000000000002 0.5681346851622322 946698,2847765,945364,945057,945181,946725,945664 25 558 2253 1.1305376344086022 1.0 1.0 99.99054131223052 GOTERM_MF_FAT GO:0046914~transitionmetalionbinding 5 10.0 0.6805816021498088 946698,945364,945057,945181,945664 25 420 2253 1.072857142857143 1.0 0.9999999999999999 99.99966093070285 SP_PIR_KEYWORDS metal-binding 5 10.0 0.8147555087687698 946698,2847765,945057,946725,945664 49 405 3548 0.8939279415469892 1.0 0.9999925145638008 99.99999861933553 Annotation Cluster 3 Enrichment Score: 0.16075939521775717 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0045333~cellularrespiration 3 6.0 0.5976277545261259 946698,946032,947528 32 152 2386 1.4716282894736843 1.0 0.9999999999997771 99.99880446858917 GOTERM_BP_FAT GO:0015980~energyderivationbyoxidationoforganiccompounds 3 6.0 0.6602311832867056 946698,946032,947528 32 170 2386 1.3158088235294116 1.0 0.9999999999003261 99.99985439836921 GOTERM_BP_FAT GO:0006091~generationofprecursormetabolitesandenergy 3 6.0 0.8348241872865093 946698,946032,947528 32 240 2386 0.9320312500000001 1.0 0.9999999999971838 99.9999999816634 Annotation Cluster 4 Enrichment Score: 0.14338399290410436 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR GOTERM_BP_FAT GO:0006355~regulationoftranscription,DNA-dependent 5 10.0 0.5049218277497715 945941,947280,947023,948917,945664 32 281 2386 1.3267348754448398 1.0 1.0 99.98420047978021 GOTERM_BP_FAT GO:0051252~regulationofRNAmetabolicprocess 5 10.0 0.50785982536817 945941,947280,947023,948917,945664 32 282 2386 1.3220301418439717 1.0 0.9999999999999983 99.9853289644228 GOTERM_BP_FAT GO:0045449~regulationoftranscription 5 10.0 0.6163699786878521 945941,947280,947023,948917,945664 32 321 2386 1.1614096573208723 1.0 0.9999999998967471 99.99933983750236 GOTERM_MF_FAT GO:0030528~transcriptionregulatoractivity 3 6.0 0.7179280067480418 945941,947280,948917 25 229 2253 1.1806113537117904 1.0 0.9999999999999531 99.99991402668238 GOTERM_BP_FAT GO:0006350~transcription 4 8.0 0.7739992375060316 945941,947280,945793,948917 32 303 2386 0.9843234323432343 1.0 0.999999999953681 99.99999909097912 GOTERM_MF_FAT GO:0003677~DNAbinding 4 8.0 0.8441489981019072 945941,947280,947023,948917 25 413 2253 0.8728329297820823 1.0 0.9999999999999998 99.99999987668276 SP_PIR_KEYWORDS dna-binding 4 8.0 0.846955080289876 945941,947280,947023,948917 49 336 3548 0.8620019436345967 1.0 0.9999945964884427 99.99999982218483 SP_PIR_KEYWORDS Transcription 3 6.0 0.9027042214533786 945941,947280,948917 49 280 3548 0.775801749271137 1.0 0.9999991516716409 99.99999999862484 SP_PIR_KEYWORDS transcriptionregulation 3 6.0 0.9038329980897641 945941,947280,948917 49 281 3548 0.7730408889534461 1.0 0.9999979818844451 99.99999999878673 Annotation Cluster 5 Enrichment Score: 0.11757783999041305 Category Term Count % Pvalue Genes List Total Pop Hits Pop Total Fold Enrichment Bonferroni Benjamini FDR SP_PIR_KEYWORDS transport 11 22.0 0.28590873569960285 946698,946716,946920,945364,948261,947238,948743,948445,948530,945181,945793 49 600 3548 1.327482993197279 0.9999999999994809 0.9999196281126327 97.30713601558003 UP_SEQ_FEATURE topologicaldomain:Cytoplasmic 7 14.000000000000002 0.6508056701225731 946920,944974,947238,948743,946353,948445,948530 49 471 3470 1.0524719441916894 1.0 0.9999999999318847 99.99890388580272 UP_SEQ_FEATURE topologicaldomain:Periplasmic 7 14.000000000000002 0.6572052971235481 946920,944974,947238,948743,946353,948445,948530 49 474 3470 1.045810729355033 1.0 0.9999999947081561 99.9991032853282 GOTERM_CC_FAT GO:0030312~externalencapsulatingstructure 8 16.0 0.677108000547278 946716,946920,945364,947238,948743,946353,948445,948530 17 659 1420 1.01401410336517 0.9999999999983504 0.999998715638107 99.98847277899155 GOTERM_CC_FAT GO:0016021~integraltomembrane 9 18.0 0.6926900807243606 946716,946920,944974,947238,948743,946353,948445,948530,1450269 17 754 1420 0.9970354189421128 0.9999999999994967 0.999920455047235 99.99224807908345 SP_PIR_KEYWORDS transmembrane 10 20.0 0.7132132116303652 946716,7751628,946920,944974,947238,948743,946353,948445,948530,1450269 49 750 3548 0.9654421768707483 1.0 0.9999979845548891 99.99984950524741 GOTERM_CC_FAT GO:0009274~peptidoglycan-basedcellwall 7 14.000000000000002 0.7398608924794248 946716,946920,947238,948743,946353,948445,948530 17 602 1420 0.9712722298221614 0.9999999999999908 0.9996900912233648 99.99796361635022 GOTERM_CC_FAT GO:0005618~cellwall 7 14.000000000000002 0.7435849678151908 946716,946920,947238,948743,946353,948445,948530 17 604 1420 0.9680560966108297 0.9999999999999934 0.9985447798055015 99.99818604972894 GOTERM_CC_FAT GO:0031224~intrinsictomembrane 9 18.0 0.8109231618860159 946716,946920,944974,947238,948743,946353,948445,948530,1450269 17 819 1420 0.9179056237879767 1.0 0.998721933874148 99.99984249601864 UP_SEQ_FEATURE transmembraneregion 9 18.0 0.8141880806788668 7751628,946920,944974,947238,948743,946353,948445,948530,1450269 49 724 3470 0.8803134513473898 1.0 0.9999999999856145 99.99999883702041 GOTERM_CC_FAT GO:0031975~envelope 6 12.0 0.8592057968035461 946716,946920,945364,947238,948743,948530 17 586 1420 0.8552499498092753 1.0 0.9987953466757498 99.99998520675663 GOTERM_CC_FAT GO:0005886~plasmamembrane 9 18.0 0.9049610308663129 946716,946920,944974,947238,948743,946353,948445,948530,1450269 17 891 1420 0.8437314319667261 1.0 0.9991415694778472 99.99999936778144 SP_PIR_KEYWORDS cellinnermembrane 7 14.000000000000002 0.9140228944934868 946920,944974,947238,948743,946353,948445,948530 49 671 3548 0.7553757717692143 1.0 0.999997456042769 99.99999999963539 SP_PIR_KEYWORDS membrane 10 20.0 0.92197457432084 946716,7751628,946920,944974,947238,948743,946353,948445,948530,1450269 49 940 3548 0.7702996092053842 1.0 0.9999966399687767 99.99999999987135 GOTERM_CC_FAT GO:0019866~organelleinnermembrane 4 8.0 0.9305930143652491 946920,947238,948743,948530 17 458 1420 0.7295145132288723 1.0 0.9991864045919726 99.99999994919638 GOTERM_CC_FAT GO:0031967~organelleenvelope 4 8.0 0.9305930143652491 946920,947238,948743,948530 17 458 1420 0.7295145132288723 1.0 0.9991864045919726 99.99999994919638 GOTERM_CC_FAT GO:0031090~organellemembrane 4 8.0 0.931362699604624 946920,947238,948743,948530 17 459 1420 0.7279251569909009 1.0 0.9983865910380072 99.99999995354368 SP_PIR_KEYWORDS cellmembrane 8 16.0 0.9740385540632627 946716,946920,944974,947238,948743,946353,948445,948530 49 889 3548 0.6515920203852069 1.0 0.9999999601708144 100.0